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A criminal psychologist (Berry) awakens to find herself a patient in the institution where she works, with no memory of the murder she’s accused of committing. As she tries to regain her memory - and her freedom - a vengeful spirit manipulates her.

Orin Boyd (Seagal) is a Detroit cop who doesn’t follow rules. After he saved the Vice President by violating every order he received he is transferred to one of the worst precincts in the city. There he quickly encounters some corrupt cops selling heroin to drug dealers. The problem is, it’s very difficult to tell who is the bad guy and who you can trust.

The nightmare isn’t over, General Cain ordered The Hive to be reopened, and in doing so contaminated all of Raccoon City, a city of the dead, with Alice stuck right in the middle. Now, along with other surviors, Jill Valentine, Carlos Oliviera and his Captain, Nicholai, they must fight to survive, to escape the nightmare that has plaqed Raccoon City. But now there is a new threat: Matt Addison has fully mutated into a seemingly unstoppable creature, code named Nemesis, who will stop at nothing until everything around it is dead, but it also has another agenda…